Drug interactions
Amoxicillin + Salsalate
Severity: Minor
Amoxicillin and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, which can reduce renal tubular secretion of penicillins and modestly raise amoxicillin levels. The effect is usually small clinically.
What this interaction means in plain words
Amoxicillin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate competes with amoxicillin for renal tubular organic anion secretion, slightly reducing amoxicillin clearance.
What to do
No routine adjustment is needed. Monitor for amoxicillin adverse effects in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Salsalate?
MediHelp rates the interaction as minor. Amoxicillin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is hydrolyzed to salicylic acid, which can reduce renal tubular secretion of penicillins and modestly raise amoxicillin levels. The effect is usually small clinically.
How serious is the interaction between Amoxicillin and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for amoxicillin adverse effects in renal impairment.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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