Drug interactions
Amoxicillin + Sodium phenylacetate
Severity: Minor
Amoxicillin and Sodium phenylacetate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are organic anions eliminated by renal tubular secretion, so they may compete and slightly slow each other's clearance. Clinical relevance is uncertain and likely small.
What this interaction means in plain words
Amoxicillin and Sodium phenylacetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular organic anion secretion; not well characterized.
What to do
No routine adjustment is needed. Monitor ammonia levels and amoxicillin tolerability in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Sodium phenylacetate?
MediHelp rates the interaction as minor. Amoxicillin and Sodium phenylacetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents are organic anions eliminated by renal tubular secretion, so they may compete and slightly slow each other's clearance. Clinical relevance is uncertain and likely small.
How serious is the interaction between Amoxicillin and Sodium phenylacetate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor ammonia levels and amoxicillin tolerability in renal impairment.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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