Drug interactions
Amoxicillin + Toripalimab
Severity: Moderate
Amoxicillin and Toripalimab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics may alter gut microbiota, and observational data in cancer patients suggest antibiotic exposure around the start of checkpoint inhibitor therapy is associated with poorer outcomes. A causal effect of a single amoxicillin course has not been established.
What this interaction means in plain words
Amoxicillin and Toripalimab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amoxicillin belongs to Anti Bacterial; Toripalimab belongs to Oncology.
Why it happens
Antibiotic-induced gut dysbiosis may impair immune responses that support checkpoint inhibitor efficacy; the mechanism is not firmly established.
What to do
Prescribe antibiotics only when clearly indicated and use the shortest effective course, especially around treatment initiation. Monitor tumor response as usual.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Other interactions of Toripalimab
- Amoxicillin-clavulanic acid + Toripalimab Moderate
- Piperacillin-tazobactam + Toripalimab Moderate
- Piperacillin + Toripalimab Moderate
Frequently asked questions
Can I take Amoxicillin with Toripalimab?
MediHelp rates the interaction as moderate. Amoxicillin and Toripalimab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics may alter gut microbiota, and observational data in cancer patients suggest antibiotic exposure around the start of checkpoint inhibitor therapy is associated with poorer outcomes. A causal effect of a single amoxicillin course has not been established.
How serious is the interaction between Amoxicillin and Toripalimab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prescribe antibiotics only when clearly indicated and use the shortest effective course, especially around treatment initiation. Monitor tumor response as usual.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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