Drug interactions
Amoxicillin + Typhoid vaccine live
Severity: Moderate
Amoxicillin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine contains viable Salmonella Typhi that must colonize the gut to induce immunity. Amoxicillin is active against many Salmonella and may reduce vaccine strain viability and the immune response.
What this interaction means in plain words
Amoxicillin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity reduces survival and replication of the live attenuated Salmonella vaccine strain.
What to do
Give the live oral typhoid vaccine only after the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Amoxicillin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine contains viable Salmonella Typhi that must colonize the gut to induce immunity. Amoxicillin is active against many Salmonella and may reduce vaccine strain viability and the immune response.
How serious is the interaction between Amoxicillin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the live oral typhoid vaccine only after the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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