Drug interactions
Amoxicillin-clavulanic acid + Sarecycline
Severity: Minor
Amoxicillin-clavulanic acid and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a bacteriostatic tetracycline for acne, with a theoretical ability to reduce penicillin bactericidal activity. Clinical evidence of problems is minimal. Significance is low for most uses.
What this interaction means in plain words
Amoxicillin-clavulanic acid and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Sarecycline belongs to Anti Bacterial.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic tetracycline and a bactericidal beta-lactam.
What to do
No routine change; monitor response to the penicillin. Consider interrupting sarecycline if a serious infection is being treated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Major
- Amoxicillin-clavulanic acid + Pexidartinib Major
- Amoxicillin-clavulanic acid + Pretomanid Major
- Allopurinol + Amoxicillin-clavulanic acid Moderate
- Amoxicillin-clavulanic acid + Bcg vaccine live Moderate
- Amoxicillin-clavulanic acid + Chloramphenicol Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Amoxicillin-clavulanic acid with Sarecycline?
MediHelp rates the interaction as minor. Amoxicillin-clavulanic acid and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a bacteriostatic tetracycline for acne, with a theoretical ability to reduce penicillin bactericidal activity. Clinical evidence of problems is minimal. Significance is low for most uses.
How serious is the interaction between Amoxicillin-clavulanic acid and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; monitor response to the penicillin. Consider interrupting sarecycline if a serious infection is being treated.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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