Drug interactions
Amphotericin b + Magnesium hydroxide
Severity: Minor
Amphotericin b and Magnesium hydroxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B promotes renal magnesium loss, which may lower serum magnesium. Magnesium hydroxide taken as an antacid or laxative would not be reliable for correcting this, and the combination has limited clinical impact.
What this interaction means in plain words
Amphotericin b and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amphotericin b belongs to Anti Fungals; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Amphotericin B tubular toxicity increases renal magnesium excretion.
What to do
Check serum magnesium periodically during amphotericin B treatment and replace deficits with a suitable supplement. Do not rely on antacid or laxative doses for repletion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Magnesium hydroxide
Frequently asked questions
Can I take Amphotericin b with Magnesium hydroxide?
MediHelp rates the interaction as minor. Amphotericin b and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amphotericin B promotes renal magnesium loss, which may lower serum magnesium. Magnesium hydroxide taken as an antacid or laxative would not be reliable for correcting this, and the combination has limited clinical impact.
How serious is the interaction between Amphotericin b and Magnesium hydroxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium periodically during amphotericin B treatment and replace deficits with a suitable supplement. Do not rely on antacid or laxative doses for repletion.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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