Drug interactions
Amphotericin b + Magnesium oxide
Severity: Minor
Amphotericin b and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B causes renal magnesium wasting and hypomagnesemia. Oral magnesium oxide may serve as replacement but is poorly absorbed and may cause diarrhea.
What this interaction means in plain words
Amphotericin b and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amphotericin b belongs to Anti Fungals; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Amphotericin-induced renal tubular injury increases urinary magnesium excretion.
What to do
Monitor serum magnesium and replace as needed; use intravenous magnesium if deficiency is significant or oral therapy is not tolerated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Amphotericin b with Magnesium oxide?
MediHelp rates the interaction as minor. Amphotericin b and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amphotericin B causes renal magnesium wasting and hypomagnesemia. Oral magnesium oxide may serve as replacement but is poorly absorbed and may cause diarrhea.
How serious is the interaction between Amphotericin b and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and replace as needed; use intravenous magnesium if deficiency is significant or oral therapy is not tolerated.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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