Drug interactions
Amphotericin b + Oxaliplatin
Severity: Moderate
Amphotericin b and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can impair renal function, and amphotericin B also causes potassium and magnesium wasting. Oxaliplatin is renally eliminated, so reduced kidney function may increase its exposure and toxicity. Nephrotoxicity of oxaliplatin alone is less than that of cisplatin.
What this interaction means in plain words
Amphotericin b and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Oxaliplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity, with reduced renal clearance of platinum.
What to do
Monitor serum creatinine, potassium and magnesium regularly. Adjust the oxaliplatin dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Amphotericin b with Oxaliplatin?
MediHelp rates the interaction as moderate. Amphotericin b and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can impair renal function, and amphotericin B also causes potassium and magnesium wasting. Oxaliplatin is renally eliminated, so reduced kidney function may increase its exposure and toxicity. Nephrotoxicity of oxaliplatin alone is less than that of cisplatin.
How serious is the interaction between Amphotericin b and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and magnesium regularly. Adjust the oxaliplatin dose if renal function declines.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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