Drug interactions
Amphotericin b + Succinylcholine
Severity: Moderate
Amphotericin b and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B frequently causes electrolyte loss, particularly potassium and magnesium. Altered electrolytes can change the response to succinylcholine, and hypokalemia may prolong or intensify neuromuscular blockade, with a risk of prolonged respiratory depression.
What this interaction means in plain words
Amphotericin b and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b belongs to Anti Fungals; Succinylcholine belongs to Musculoskeletal.
Why it happens
Electrolyte disturbances caused by amphotericin B indirectly modify neuromuscular transmission and the response to depolarizing blockade.
What to do
Measure and replace potassium and magnesium before anesthesia. Monitor neuromuscular recovery and ensure ventilatory support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b and Succinylcholine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amphotericin b
- Amphotericin b + Cidofovir Contraindicated
- Adefovir + Amphotericin b Major
- Amikacin + Amphotericin b Major
- Amphotericin b + Arsenic trioxide Major
- Amphotericin b + Capreomycin Major
- Amphotericin b + Cephaloridine Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Amphotericin b with Succinylcholine?
MediHelp rates the interaction as moderate. Amphotericin b and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B frequently causes electrolyte loss, particularly potassium and magnesium. Altered electrolytes can change the response to succinylcholine, and hypokalemia may prolong or intensify neuromuscular blockade, with a risk of prolonged respiratory depression.
How serious is the interaction between Amphotericin b and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure and replace potassium and magnesium before anesthesia. Monitor neuromuscular recovery and ensure ventilatory support is available.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
