Drug interactions
Amphotericin b liposomal + Dichlorphenamide
Severity: Moderate
Amphotericin b liposomal and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide promotes renal potassium loss and metabolic acidosis, and amphotericin B also causes hypokalemia and renal tubular toxicity. Together they may produce clinically significant hypokalemia and worsen acid-base disturbance.
What this interaction means in plain words
Amphotericin b liposomal and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting and tubular effects, with carbonic anhydrase inhibition adding metabolic acidosis.
What to do
Monitor serum potassium, bicarbonate and renal function regularly. Replace potassium as needed and reduce the dichlorphenamide dose if acidosis or hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Moderate
- Amphotericin b liposomal + Benazepril Moderate
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Moderate
- Amphotericin b liposomal + Deflazacort Moderate
- Amphotericin b liposomal + Ifosfamide Moderate
- Amphotericin b liposomal + Lomustine Moderate
Frequently asked questions
Can I take Amphotericin b liposomal with Dichlorphenamide?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide promotes renal potassium loss and metabolic acidosis, and amphotericin B also causes hypokalemia and renal tubular toxicity. Together they may produce clinically significant hypokalemia and worsen acid-base disturbance.
How serious is the interaction between Amphotericin b liposomal and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, bicarbonate and renal function regularly. Replace potassium as needed and reduce the dichlorphenamide dose if acidosis or hypokalemia persists.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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