Drug interactions
Amphotericin b liposomal + Ifosfamide
Severity: Moderate
Amphotericin b liposomal and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, so combined use may increase the risk of renal impairment. Infusion-related reactions such as bronchospasm and hypotension are also described with amphotericin.
What this interaction means in plain words
Amphotericin b liposomal and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Ifosfamide belongs to Oncology.
Why it happens
Additive nephrotoxicity; the mechanism for any other enhanced toxicity is not established.
What to do
Monitor serum creatinine, electrolytes (potassium, magnesium) and urine output regularly, and maintain adequate hydration. Consider an alternative antifungal if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b liposomal and Ifosfamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Moderate
- Amphotericin b liposomal + Benazepril Moderate
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Moderate
- Amphotericin b liposomal + Deflazacort Moderate
- Amphotericin b liposomal + Dichlorphenamide Moderate
- Amphotericin b liposomal + Lomustine Moderate
Frequently asked questions
Can I take Amphotericin b liposomal with Ifosfamide?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, so combined use may increase the risk of renal impairment. Infusion-related reactions such as bronchospasm and hypotension are also described with amphotericin.
How serious is the interaction between Amphotericin b liposomal and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, electrolytes (potassium, magnesium) and urine output regularly, and maintain adequate hydration. Consider an alternative antifungal if renal function declines.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
