Drug interactions
Amphotericin b liposomal + Deflazacort
Severity: Moderate
Amphotericin b liposomal and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote potassium loss, and together hypokalemia can be more severe. This can provoke weakness and cardiac arrhythmias.
What this interaction means in plain words
Amphotericin b liposomal and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Deflazacort belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from corticosteroid mineralocorticoid effect and amphotericin-induced tubular toxicity.
What to do
Monitor serum potassium and magnesium regularly and replace as needed. Take extra care in patients on digoxin or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Moderate
- Amphotericin b liposomal + Benazepril Moderate
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Moderate
- Amphotericin b liposomal + Dichlorphenamide Moderate
- Amphotericin b liposomal + Ifosfamide Moderate
- Amphotericin b liposomal + Lomustine Moderate
Frequently asked questions
Can I take Amphotericin b liposomal with Deflazacort?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote potassium loss, and together hypokalemia can be more severe. This can provoke weakness and cardiac arrhythmias.
How serious is the interaction between Amphotericin b liposomal and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace as needed. Take extra care in patients on digoxin or other QT-prolonging drugs.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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