Drug interactions
Amphotericin b liposomal + Benazepril
Severity: Moderate
Amphotericin b liposomal and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphotericin B can cause infusion-related hypotension and renal toxicity, which may be amplified by an ACE inhibitor. Volume depletion and reduced renal function increase the likelihood of problems.
What this interaction means in plain words
Amphotericin b liposomal and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amphotericin b liposomal belongs to Anti Fungals; Benazepril belongs to Cardiovascular.
Why it happens
Additive hypotensive effect, with amphotericin nephrotoxicity and ACE inhibitor loss of efferent arteriolar tone compounding renal risk.
What to do
Monitor blood pressure, serum creatinine and potassium during amphotericin therapy and temporarily hold benazepril if hypotension or renal decline develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Amphotericin b liposomal
- Amlodipine-benazepril + Amphotericin b liposomal Moderate
- Amphotericin b liposomal + Captopril-hydrochlorothiazide Moderate
- Amphotericin b liposomal + Deflazacort Moderate
- Amphotericin b liposomal + Dichlorphenamide Moderate
- Amphotericin b liposomal + Ifosfamide Moderate
- Amphotericin b liposomal + Lomustine Moderate
Frequently asked questions
Can I take Amphotericin b liposomal with Benazepril?
MediHelp rates the interaction as moderate. Amphotericin b liposomal and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphotericin B can cause infusion-related hypotension and renal toxicity, which may be amplified by an ACE inhibitor. Volume depletion and reduced renal function increase the likelihood of problems.
How serious is the interaction between Amphotericin b liposomal and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium during amphotericin therapy and temporarily hold benazepril if hypotension or renal decline develops.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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