Drug interactions
Ampicillin-sulbactam + Sarecycline
Severity: Minor
Ampicillin-sulbactam and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a bacteriostatic tetracycline used for acne and is theoretically able to reduce the bactericidal effect of penicillins. Systemic exposure is modest and clinical evidence of treatment failure is lacking. The practical relevance is low unless a serious infection is being treated.
What this interaction means in plain words
Ampicillin-sulbactam and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ampicillin-sulbactam belongs to Anti Bacterial; Sarecycline belongs to Anti Bacterial.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic tetracycline and a bactericidal beta-lactam that requires bacterial growth.
What to do
No routine change is needed for short courses; monitor response to the beta-lactam. For severe infections, consider whether sarecycline can be paused during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ampicillin-sulbactam and Sarecycline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ampicillin-sulbactam
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Ampicillin-sulbactam with Sarecycline?
MediHelp rates the interaction as minor. Ampicillin-sulbactam and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a bacteriostatic tetracycline used for acne and is theoretically able to reduce the bactericidal effect of penicillins. Systemic exposure is modest and clinical evidence of treatment failure is lacking. The practical relevance is low unless a serious infection is being treated.
How serious is the interaction between Ampicillin-sulbactam and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for short courses; monitor response to the beta-lactam. For severe infections, consider whether sarecycline can be paused during treatment.
What other medicines interact with Ampicillin-sulbactam?
MediHelp also lists interactions of Ampicillin-sulbactam with, for example, Methotrexate, Allopurinol, Bcg vaccine live. The full list is on the Ampicillin-sulbactam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
