Drug interactions
Anagrelide + Apixaban
Severity: Moderate
Anagrelide and Apixaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide lowers platelet counts and has some antiplatelet activity, which may add to the bleeding risk of apixaban. The effect is plausible but based on limited data.
What this interaction means in plain words
Anagrelide and Apixaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Apixaban belongs to Cardiovascular.
Why it happens
Platelet reduction and inhibition of aggregation by anagrelide add to factor Xa inhibition.
What to do
Monitor platelet counts and for signs of bleeding. Reassess the need for both agents if thrombocytopenia or bleeding develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Apixaban?
MediHelp rates the interaction as moderate. Anagrelide and Apixaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide lowers platelet counts and has some antiplatelet activity, which may add to the bleeding risk of apixaban. The effect is plausible but based on limited data.
How serious is the interaction between Anagrelide and Apixaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and for signs of bleeding. Reassess the need for both agents if thrombocytopenia or bleeding develops.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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