Drug interactions
Anagrelide + Aripiprazole
Severity: Moderate
Anagrelide and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide is associated with QT prolongation, tachycardia and palpitations. Aripiprazole has a low QT liability, so the additive risk is small but may matter in patients with other cardiac risk factors.
What this interaction means in plain words
Anagrelide and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Aripiprazole belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation; anagrelide is the main contributor.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor for palpitations and syncope, especially with other QT-prolonging drugs or heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Aripiprazole?
MediHelp rates the interaction as moderate. Anagrelide and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide is associated with QT prolongation, tachycardia and palpitations. Aripiprazole has a low QT liability, so the additive risk is small but may matter in patients with other cardiac risk factors.
How serious is the interaction between Anagrelide and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor for palpitations and syncope, especially with other QT-prolonging drugs or heart disease.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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