Drug interactions
Anagrelide + Doxepin
Severity: Moderate
Anagrelide and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Doxepin, a tricyclic antidepressant, also has anticholinergic and arrhythmogenic effects, so combined use may raise the risk of ventricular arrhythmia, especially at higher doses.
What this interaction means in plain words
Anagrelide and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Doxepin belongs to Dermatology.
Why it happens
Additive QT prolongation and cardiac conduction effects.
What to do
Obtain a baseline ECG and monitor the QTc, potassium and magnesium. Use the lowest doxepin dose, or choose an alternative in patients with cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Anagrelide with Doxepin?
MediHelp rates the interaction as moderate. Anagrelide and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Doxepin, a tricyclic antidepressant, also has anticholinergic and arrhythmogenic effects, so combined use may raise the risk of ventricular arrhythmia, especially at higher doses.
How serious is the interaction between Anagrelide and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc, potassium and magnesium. Use the lowest doxepin dose, or choose an alternative in patients with cardiac risk.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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