Drug interactions
Anagrelide + Fluoxetine
Severity: Moderate
Anagrelide and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can cause QT prolongation, tachycardia and palpitations, and fluoxetine may add to the QT effect. Fluoxetine also weakly inhibits CYP1A2, the main enzyme metabolizing anagrelide, which could raise anagrelide exposure.
What this interaction means in plain words
Anagrelide and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with possible reduced anagrelide clearance via CYP1A2 inhibition.
What to do
Obtain a baseline ECG and monitor QTc and heart rate when combining. Correct electrolyte abnormalities and reduce the anagrelide dose if cardiac adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anagrelide and Fluoxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Fluoxetine?
MediHelp rates the interaction as moderate. Anagrelide and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide can cause QT prolongation, tachycardia and palpitations, and fluoxetine may add to the QT effect. Fluoxetine also weakly inhibits CYP1A2, the main enzyme metabolizing anagrelide, which could raise anagrelide exposure.
How serious is the interaction between Anagrelide and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and heart rate when combining. Correct electrolyte abnormalities and reduce the anagrelide dose if cardiac adverse effects emerge.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
