Drug interactions
Anagrelide + Ibutilide
Severity: Major
Anagrelide and Ibutilide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide is a class III antiarrhythmic with a well-known risk of torsades de pointes, and anagrelide adds further QT prolongation. Together they increase the risk of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Anagrelide and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Ibutilide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization and the QT interval.
What to do
Avoid the combination. If ibutilide is needed for cardioversion, consider holding anagrelide and use continuous ECG monitoring with electrolytes corrected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Anagrelide with Ibutilide?
MediHelp rates the interaction as major. Anagrelide and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide is a class III antiarrhythmic with a well-known risk of torsades de pointes, and anagrelide adds further QT prolongation. Together they increase the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Anagrelide and Ibutilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If ibutilide is needed for cardioversion, consider holding anagrelide and use continuous ECG monitoring with electrolytes corrected.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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