Drug interactions
Chlorpromazine + Panobinostat
Severity: Contraindicated
Chlorpromazine and Panobinostat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and chlorpromazine has the same effect, so using both increases the risk of torsade de pointes. Panobinostat labeling advises against use with QT-prolonging drugs.
What this interaction means in plain words
Chlorpromazine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chlorpromazine belongs to Central Nervous System; Panobinostat belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Do not use together; choose an antipsychotic or antiemetic without QT effect. If unavoidable, monitor ECG and electrolytes intensively.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Pimozide Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Moxifloxacin + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Panobinostat?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat prolongs the QT interval and chlorpromazine has the same effect, so using both increases the risk of torsade de pointes. Panobinostat labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Chlorpromazine and Panobinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an antipsychotic or antiemetic without QT effect. If unavoidable, monitor ECG and electrolytes intensively.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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