Drug interactions
Dronedarone + Panobinostat
Severity: Contraindicated
Dronedarone and Panobinostat: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and panobinostat carries a labeled warning against use with QT-prolonging agents. Combined use increases the risk of torsades de pointes.
What this interaction means in plain words
Dronedarone and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Panobinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation; dronedarone's CYP3A4 inhibition may also raise panobinostat levels.
What to do
Avoid the combination and use an alternative antiarrhythmic during panobinostat therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Moxifloxacin + Panobinostat Contraindicated
Frequently asked questions
Can I take Dronedarone with Panobinostat?
MediHelp rates the interaction as contraindicated. Dronedarone and Panobinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and panobinostat carries a labeled warning against use with QT-prolonging agents. Combined use increases the risk of torsades de pointes.
How serious is the interaction between Dronedarone and Panobinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiarrhythmic during panobinostat therapy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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