Drug interactions
Anagrelide + Propafenone
Severity: Major
Anagrelide and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so taking them together may increase the risk of torsades de pointes and other ventricular arrhythmias. Anagrelide can also cause tachycardia and palpitations, which adds to the proarrhythmic burden in a patient on a class 1C antiarrhythmic.
What this interaction means in plain words
Anagrelide and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Propafenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation and proarrhythmic effects.
What to do
Avoid the combination where an alternative exists. If it is unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Propafenone?
MediHelp rates the interaction as major. Anagrelide and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so taking them together may increase the risk of torsades de pointes and other ventricular arrhythmias. Anagrelide can also cause tachycardia and palpitations, which adds to the proarrhythmic burden in a patient on a class 1C antiarrhythmic.
How serious is the interaction between Anagrelide and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If it is unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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