Drug interactions
Anagrelide + Sertraline
Severity: Moderate
Anagrelide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide can prolong the QT interval and cause palpitations and tachyarrhythmias. Sertraline may add a modest QT effect, so the combination can raise the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Anagrelide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation; both drugs affect cardiac repolarization.
What to do
Check a baseline ECG and electrolytes before starting and monitor the ECG during treatment. Consider an alternative antidepressant in patients with existing QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Sertraline?
MediHelp rates the interaction as moderate. Anagrelide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide can prolong the QT interval and cause palpitations and tachyarrhythmias. Sertraline may add a modest QT effect, so the combination can raise the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Anagrelide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes before starting and monitor the ECG during treatment. Consider an alternative antidepressant in patients with existing QT risk factors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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