Drug interactions
Anagrelide + Warfarin
Severity: Moderate
Anagrelide and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anagrelide inhibits platelet aggregation and can add to the bleeding tendency of warfarin. The risk is mainly an increased chance of haemorrhage rather than a change in INR.
What this interaction means in plain words
Anagrelide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anagrelide belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect of platelet inhibition (via phosphodiesterase 3 inhibition) with anticoagulation.
What to do
Monitor for bleeding signs and check INR and platelet count regularly. Reassess the need for both drugs if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Frequently asked questions
Can I take Anagrelide with Warfarin?
MediHelp rates the interaction as moderate. Anagrelide and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anagrelide inhibits platelet aggregation and can add to the bleeding tendency of warfarin. The risk is mainly an increased chance of haemorrhage rather than a change in INR.
How serious is the interaction between Anagrelide and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and check INR and platelet count regularly. Reassess the need for both drugs if bleeding occurs.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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