Drug interactions
Anakinra + Tacrolimus
Severity: Moderate
Anakinra and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined IL-1 blockade and calcineurin inhibition increases global immunosuppression and infection risk. Clinical experience is limited to selected cases.
What this interaction means in plain words
Anakinra and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive immunosuppression via IL-1 receptor antagonism and calcineurin inhibition.
What to do
Monitor for infection and neutrophil counts, along with tacrolimus trough levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Anakinra with Tacrolimus?
MediHelp rates the interaction as moderate. Anakinra and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined IL-1 blockade and calcineurin inhibition increases global immunosuppression and infection risk. Clinical experience is limited to selected cases.
How serious is the interaction between Anakinra and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and neutrophil counts, along with tacrolimus trough levels.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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