Drug interactions
Anakinra + Trastuzumab deruxtecan
Severity: Moderate
Anakinra and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan commonly causes neutropenia, and anakinra can itself reduce neutrophil counts and increase infection susceptibility. Together they may increase the risk of serious infection.
What this interaction means in plain words
Anakinra and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anakinra belongs to Musculoskeletal; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive and immunosuppressive effects; no specific pharmacokinetic interaction is known.
What to do
Monitor neutrophil counts regularly and evaluate promptly for infection or fever. Interrupt or adjust therapy according to neutropenia severity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anakinra
- Anakinra + Bcg vaccine live Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine live Contraindicated
- Anakinra + Measles mumps rubella and varicella vaccine live Contraindicated
- Anakinra + Measles vaccine Contraindicated
- Abatacept + Anakinra Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Anakinra with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Anakinra and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan commonly causes neutropenia, and anakinra can itself reduce neutrophil counts and increase infection susceptibility. Together they may increase the risk of serious infection.
How serious is the interaction between Anakinra and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts regularly and evaluate promptly for infection or fever. Interrupt or adjust therapy according to neutropenia severity.
What other medicines interact with Anakinra?
MediHelp also lists interactions of Anakinra with, for example, Bcg vaccine live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Anakinra page.
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