Drug interactions
Anastrozole + Itraconazole
Severity: Minor
Anastrozole and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anastrozole is not a clinically meaningful CYP3A4 inhibitor, so it is unlikely to change itraconazole levels. No important interaction is expected.
What this interaction means in plain words
Anastrozole and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Anastrozole belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
No established mechanism; anastrozole has only weak in vitro CYP inhibition that is not clinically relevant.
What to do
No action beyond routine monitoring of therapy is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Anastrozole and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Anastrozole
- Anastrozole + Bazedoxifene / conjugated estrogens Contraindicated
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Anastrozole + Conjugated estrogens Contraindicated
- Anastrozole + Estradiol Contraindicated
- Anastrozole + Estrogens conjugated synthetic Contraindicated
- Anastrozole + Estrogens esterified Contraindicated
Frequently asked questions
Can I take Anastrozole with Itraconazole?
MediHelp rates the interaction as minor. Anastrozole and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anastrozole is not a clinically meaningful CYP3A4 inhibitor, so it is unlikely to change itraconazole levels. No important interaction is expected.
How serious is the interaction between Anastrozole and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action beyond routine monitoring of therapy is needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
