Drug interactions
Anastrozole + Midazolam
Severity: Minor
Anastrozole and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anastrozole has little clinically meaningful effect on CYP3A4 and is not expected to raise midazolam exposure appreciably. No significant effect on midazolam response is established.
What this interaction means in plain words
Anastrozole and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Anastrozole belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Weak in vitro CYP inhibition by anastrozole is not shown to be clinically significant.
What to do
No dose adjustment is needed; use usual midazolam monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Anastrozole
- Anastrozole + Bazedoxifene / conjugated estrogens Contraindicated
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Anastrozole + Conjugated estrogens Contraindicated
- Anastrozole + Estradiol Contraindicated
- Anastrozole + Estrogens conjugated synthetic Contraindicated
- Anastrozole + Estrogens esterified Contraindicated
Frequently asked questions
Can I take Anastrozole with Midazolam?
MediHelp rates the interaction as minor. Anastrozole and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anastrozole has little clinically meaningful effect on CYP3A4 and is not expected to raise midazolam exposure appreciably. No significant effect on midazolam response is established.
How serious is the interaction between Anastrozole and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; use usual midazolam monitoring.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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