Drug interactions
Androstenedione + Estradiol
Severity: Minor
Androstenedione and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androstenedione is a precursor that can be converted to estrogens and testosterone, so it may add to estrogenic effects. The clinical consequence with prescribed estradiol is unclear and likely small.
What this interaction means in plain words
Androstenedione and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Peripheral aromatization of androstenedione to estrone and estradiol adds to total estrogenic activity.
What to do
Avoid unneeded androstenedione supplements and monitor for estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Androstenedione with Estradiol?
MediHelp rates the interaction as minor. Androstenedione and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Androstenedione is a precursor that can be converted to estrogens and testosterone, so it may add to estrogenic effects. The clinical consequence with prescribed estradiol is unclear and likely small.
How serious is the interaction between Androstenedione and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unneeded androstenedione supplements and monitor for estrogenic adverse effects.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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