Drug interactions
Anthrax vaccine + Temsirolimus
Severity: Moderate
Anthrax vaccine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus is an mTOR inhibitor with immunosuppressive activity and may blunt the antibody response to non-live vaccines such as anthrax vaccine. Protection may therefore be reduced or absent after immunization during therapy.
What this interaction means in plain words
Anthrax vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
mTOR inhibition suppresses T- and B-cell proliferation and so impairs the development of vaccine-induced immunity.
What to do
Where possible, give needed inactivated vaccines before starting temsirolimus. If vaccinated during therapy, consider checking antibody response or repeating the dose after immunosuppression ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Anthrax vaccine with Temsirolimus?
MediHelp rates the interaction as moderate. Anthrax vaccine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus is an mTOR inhibitor with immunosuppressive activity and may blunt the antibody response to non-live vaccines such as anthrax vaccine. Protection may therefore be reduced or absent after immunization during therapy.
How serious is the interaction between Anthrax vaccine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give needed inactivated vaccines before starting temsirolimus. If vaccinated during therapy, consider checking antibody response or repeating the dose after immunosuppression ends.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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