Drug interactions
Anti-thymocyte + Ublituximab
Severity: Moderate
Anti-thymocyte and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress immune function, with ATG depleting T cells and ublituximab depleting B cells. Used together or in close sequence, they can deepen immunosuppression and raise the risk of serious infections, including opportunistic infections.
What this interaction means in plain words
Anti-thymocyte and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Anti-thymocyte belongs to Miscellaneous; Ublituximab belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic immunosuppression through T-cell depletion and CD20-mediated B-cell depletion.
What to do
Avoid concurrent use where possible and allow for the prolonged duration of effect of each agent when sequencing them. Monitor for signs of infection and consider antimicrobial prophylaxis and checking immunoglobulin and lymphocyte counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Bcg vaccine live Contraindicated
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
Other interactions of Ublituximab
Frequently asked questions
Can I take Anti-thymocyte with Ublituximab?
MediHelp rates the interaction as moderate. Anti-thymocyte and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress immune function, with ATG depleting T cells and ublituximab depleting B cells. Used together or in close sequence, they can deepen immunosuppression and raise the risk of serious infections, including opportunistic infections.
How serious is the interaction between Anti-thymocyte and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and allow for the prolonged duration of effect of each agent when sequencing them. Monitor for signs of infection and consider antimicrobial prophylaxis and checking immunoglobulin and lymphocyte counts.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.
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