Drug interactions
Antipyrine + Zileuton
Severity: Minor
Antipyrine and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton inhibits CYP1A2 and may slow antipyrine metabolism, as antipyrine is partly cleared by this enzyme. Antipyrine is mainly used as a research probe, so clinical relevance is minimal.
What this interaction means in plain words
Antipyrine and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP1A2 by zileuton reduces antipyrine clearance.
What to do
No action is needed beyond awareness. Interpret antipyrine-based metabolic testing cautiously in patients taking zileuton.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Frequently asked questions
Can I take Antipyrine with Zileuton?
MediHelp rates the interaction as minor. Antipyrine and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zileuton inhibits CYP1A2 and may slow antipyrine metabolism, as antipyrine is partly cleared by this enzyme. Antipyrine is mainly used as a research probe, so clinical relevance is minimal.
How serious is the interaction between Antipyrine and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond awareness. Interpret antipyrine-based metabolic testing cautiously in patients taking zileuton.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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