Drug interactions
Antithrombin iii + Vortioxetine
Severity: Moderate
Antithrombin iii and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antithrombin III enhances inhibition of coagulation factors, increasing bleeding risk. Vortioxetine, like other serotonergic antidepressants, can impair platelet function and may add to the bleeding tendency.
What this interaction means in plain words
Antithrombin iii and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: enhanced anticoagulation from antithrombin plus platelet serotonin depletion from vortioxetine.
What to do
Monitor for bruising, mucosal or other bleeding and follow coagulation tests as indicated for antithrombin therapy. Reassess the combination if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Antithrombin iii with Vortioxetine?
MediHelp rates the interaction as moderate. Antithrombin iii and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antithrombin III enhances inhibition of coagulation factors, increasing bleeding risk. Vortioxetine, like other serotonergic antidepressants, can impair platelet function and may add to the bleeding tendency.
How serious is the interaction between Antithrombin iii and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, mucosal or other bleeding and follow coagulation tests as indicated for antithrombin therapy. Reassess the combination if bleeding occurs.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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