Drug interactions
Antithymocyte globulin equine + Golimumab
Severity: Major
Antithymocyte globulin equine and Golimumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Equine antithymocyte globulin profoundly depletes T cells, and golimumab adds TNF blockade. The combination raises the risk of serious and opportunistic infections. It is rarely intended and should be reserved for exceptional cases.
What this interaction means in plain words
Antithymocyte globulin equine and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from profound T-cell depletion and TNF inhibition.
What to do
Avoid the combination and consider holding golimumab during and after ATG therapy. If both are given, monitor closely for infection and consider antimicrobial prophylaxis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin equine with Golimumab?
MediHelp rates the interaction as major. Antithymocyte globulin equine and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Equine antithymocyte globulin profoundly depletes T cells, and golimumab adds TNF blockade. The combination raises the risk of serious and opportunistic infections. It is rarely intended and should be reserved for exceptional cases.
How serious is the interaction between Antithymocyte globulin equine and Golimumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider holding golimumab during and after ATG therapy. If both are given, monitor closely for infection and consider antimicrobial prophylaxis.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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