Drug interactions
Golimumab + Influenza virus vaccine quadrivalent intranasal
Severity: Contraindicated
Golimumab and Influenza virus vaccine quadrivalent intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus. In patients immunosuppressed by golimumab, the vaccine strain could replicate and cause disease, and the immune response may also be reduced.
What this interaction means in plain words
Golimumab and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF-alpha blockade impairs immune control of replicating live attenuated vaccine virus.
What to do
Do not give the live intranasal vaccine to patients on golimumab; use an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
- Golimumab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Golimumab with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as contraindicated. Golimumab and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus. In patients immunosuppressed by golimumab, the vaccine strain could replicate and cause disease, and the immune response may also be reduced.
How serious is the interaction between Golimumab and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live intranasal vaccine to patients on golimumab; use an inactivated injectable influenza vaccine instead.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Measles mumps and rubella vaccine. The full list is on the Golimumab page.
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