Drug interactions
Antithymocyte globulin equine + Infliximab
Severity: Major
Antithymocyte globulin equine and Infliximab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Equine antithymocyte globulin profoundly depletes T cells, and adding infliximab increases the risk of serious opportunistic infections and possibly malignancy. Overimmunosuppression is the main concern.
What this interaction means in plain words
Antithymocyte globulin equine and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion and TNF-alpha blockade.
What to do
Avoid concurrent use unless clearly needed. If used together, give infection prophylaxis as appropriate and monitor closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin equine with Infliximab?
MediHelp rates the interaction as major. Antithymocyte globulin equine and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Equine antithymocyte globulin profoundly depletes T cells, and adding infliximab increases the risk of serious opportunistic infections and possibly malignancy. Overimmunosuppression is the main concern.
How serious is the interaction between Antithymocyte globulin equine and Infliximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless clearly needed. If used together, give infection prophylaxis as appropriate and monitor closely for infection.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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