Drug interactions
Antithymocyte globulin equine + Ocrelizumab
Severity: Major
Antithymocyte globulin equine and Ocrelizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are strongly immunosuppressive, so combined use increases the risk of serious and opportunistic infections. T-cell depletion with ATG adds to B-cell depletion from ocrelizumab.
What this interaction means in plain words
Antithymocyte globulin equine and Ocrelizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression through T-cell depletion by ATG and B-cell depletion by ocrelizumab.
What to do
Avoid concurrent use where possible, and screen and monitor closely for infection if combined. Consider the persistent effect of ocrelizumab when planning later immunosuppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Antithymocyte globulin equine with Ocrelizumab?
MediHelp rates the interaction as major. Antithymocyte globulin equine and Ocrelizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are strongly immunosuppressive, so combined use increases the risk of serious and opportunistic infections. T-cell depletion with ATG adds to B-cell depletion from ocrelizumab.
How serious is the interaction between Antithymocyte globulin equine and Ocrelizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, and screen and monitor closely for infection if combined. Consider the persistent effect of ocrelizumab when planning later immunosuppression.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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