Drug interactions
Influenza virus vaccine quadrivalent intranasal + Ocrelizumab
Severity: Contraindicated
Influenza virus vaccine quadrivalent intranasal and Ocrelizumab: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, which can replicate in a patient whose immune system is suppressed by B-cell depletion. This creates a risk of vaccine-strain infection and a poor immune response.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Ocrelizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Ocrelizumab-induced immunosuppression allows uncontrolled replication of live attenuated vaccine virus and impairs vaccine response.
What to do
Do not give live intranasal influenza vaccine during ocrelizumab therapy or until B-cell repletion; use an inactivated injectable vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
- Antithymocyte globulin equine + Ocrelizumab Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Ocrelizumab?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Ocrelizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which can replicate in a patient whose immune system is suppressed by B-cell depletion. This creates a risk of vaccine-strain infection and a poor immune response.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Ocrelizumab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live intranasal influenza vaccine during ocrelizumab therapy or until B-cell repletion; use an inactivated injectable vaccine instead.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Ocrelizumab page.
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