Drug interactions
Measles mumps rubella and varicella vaccine live + Ocrelizumab
Severity: Contraindicated
Measles mumps rubella and varicella vaccine live and Ocrelizumab: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The MMRV vaccine contains live attenuated viruses, which may cause disease in a patient with B-cell depletion while the immune response is also impaired.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Ocrelizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Ocrelizumab-induced immunosuppression permits replication of live attenuated vaccine viruses and reduces the vaccine response.
What to do
Do not give live vaccines during ocrelizumab therapy or until B-cell repletion. Give live vaccines at least 4 weeks before starting ocrelizumab when needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
- Antithymocyte globulin equine + Ocrelizumab Major
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Ocrelizumab?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Ocrelizumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The MMRV vaccine contains live attenuated viruses, which may cause disease in a patient with B-cell depletion while the immune response is also impaired.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Ocrelizumab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during ocrelizumab therapy or until B-cell repletion. Give live vaccines at least 4 weeks before starting ocrelizumab when needed.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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