Drug interactions
Antithymocyte globulin rabbit + Everolimus
Severity: Major
Antithymocyte globulin rabbit and Everolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabbit antithymocyte globulin depletes T cells and everolimus adds mTOR-mediated immunosuppression. The combination raises the risk of serious infection and malignancy.
What this interaction means in plain words
Antithymocyte globulin rabbit and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from T-cell depletion and mTOR inhibition.
What to do
Use only within established transplant protocols with antimicrobial prophylaxis and monitoring for infection. Outside such protocols avoid the combination.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Antithymocyte globulin rabbit with Everolimus?
MediHelp rates the interaction as major. Antithymocyte globulin rabbit and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rabbit antithymocyte globulin depletes T cells and everolimus adds mTOR-mediated immunosuppression. The combination raises the risk of serious infection and malignancy.
How serious is the interaction between Antithymocyte globulin rabbit and Everolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only within established transplant protocols with antimicrobial prophylaxis and monitoring for infection. Outside such protocols avoid the combination.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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