Drug interactions
Bcg vaccine live + Everolimus
Severity: Contraindicated
Bcg vaccine live and Everolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live BCG vaccine in a patient on everolimus risks disseminated BCG infection because of impaired cell-mediated immunity. The vaccine response may also be reduced.
What this interaction means in plain words
Bcg vaccine live and Everolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR inhibition-related immunosuppression allows uncontrolled replication of the live attenuated mycobacteria.
What to do
Do not give live BCG vaccine during everolimus therapy. Complete any needed live vaccinations before starting treatment, observing the recommended interval.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Everolimus
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
- Everolimus + Ritonavir Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Everolimus?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Everolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live BCG vaccine in a patient on everolimus risks disseminated BCG infection because of impaired cell-mediated immunity. The vaccine response may also be reduced.
How serious is the interaction between Bcg vaccine live and Everolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live BCG vaccine during everolimus therapy. Complete any needed live vaccinations before starting treatment, observing the recommended interval.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole, Measles mumps and rubella vaccine live. The full list is on the Everolimus page.
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