Drug interactions
Everolimus + Measles mumps and rubella vaccine live
Severity: Contraindicated
Everolimus and Measles mumps and rubella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live attenuated vaccine can cause disseminated vaccine-strain infection in patients immunosuppressed by everolimus, and the immune response may also be reduced.
What this interaction means in plain words
Everolimus and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression from mTOR inhibition impairs control of live attenuated virus replication and reduces vaccine response.
What to do
Do not administer during everolimus therapy. Give at least several weeks before starting everolimus where feasible, and check immunity serologically if exposure occurs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
- Everolimus + Ritonavir Contraindicated
Frequently asked questions
Can I take Everolimus with Measles mumps and rubella vaccine live?
MediHelp rates the interaction as contraindicated. Everolimus and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This live attenuated vaccine can cause disseminated vaccine-strain infection in patients immunosuppressed by everolimus, and the immune response may also be reduced.
How serious is the interaction between Everolimus and Measles mumps and rubella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during everolimus therapy. Give at least several weeks before starting everolimus where feasible, and check immunity serologically if exposure occurs.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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