Drug interactions
Apalutamide + Benzphetamine
Severity: Minor
Apalutamide and Benzphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is thought to be partly metabolized by CYP3A4, and apalutamide strongly induces this enzyme. Any resulting change in anorectic effect is likely limited and poorly documented.
What this interaction means in plain words
Apalutamide and Benzphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Apalutamide may induce CYP3A4-mediated metabolism of benzphetamine; the extent is not well established.
What to do
No routine dose change is required. Monitor for reduced weight-loss response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Benzphetamine?
MediHelp rates the interaction as minor. Apalutamide and Benzphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Benzphetamine is thought to be partly metabolized by CYP3A4, and apalutamide strongly induces this enzyme. Any resulting change in anorectic effect is likely limited and poorly documented.
How serious is the interaction between Apalutamide and Benzphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor for reduced weight-loss response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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