Drug interactions
Apalutamide + Budesonide
Severity: Moderate
Apalutamide and Budesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can substantially lower budesonide exposure, especially for the oral form with its extensive first-pass metabolism. This may lead to loss of disease control.
What this interaction means in plain words
Apalutamide and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Budesonide belongs to Respiratory.
Why it happens
Induction of hepatic and intestinal CYP3A4 increases budesonide metabolism.
What to do
Monitor for reduced budesonide efficacy and consider an alternative corticosteroid or dose adjustment if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Budesonide?
MediHelp rates the interaction as moderate. Apalutamide and Budesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can substantially lower budesonide exposure, especially for the oral form with its extensive first-pass metabolism. This may lead to loss of disease control.
How serious is the interaction between Apalutamide and Budesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced budesonide efficacy and consider an alternative corticosteroid or dose adjustment if control is lost.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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