Drug interactions
Apalutamide + Buprenorphine buccal
Severity: Moderate
Apalutamide and Buprenorphine buccal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine is metabolized by CYP3A4, and apalutamide is a strong inducer. Lower buprenorphine levels may cause reduced analgesia or opioid withdrawal symptoms.
What this interaction means in plain words
Apalutamide and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Apalutamide induces CYP3A4, increasing buprenorphine N-dealkylation.
What to do
Monitor for withdrawal symptoms or inadequate pain control and adjust the buprenorphine dose as needed. Re-evaluate dosing when apalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Apalutamide and Buprenorphine buccal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Buprenorphine buccal?
MediHelp rates the interaction as moderate. Apalutamide and Buprenorphine buccal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine is metabolized by CYP3A4, and apalutamide is a strong inducer. Lower buprenorphine levels may cause reduced analgesia or opioid withdrawal symptoms.
How serious is the interaction between Apalutamide and Buprenorphine buccal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or inadequate pain control and adjust the buprenorphine dose as needed. Re-evaluate dosing when apalutamide is discontinued.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
