Drug interactions
Apalutamide + Buprenorphine long-acting
Severity: Moderate
Apalutamide and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce buprenorphine concentrations from long-acting injection through enzyme induction. This could cause withdrawal symptoms or reduced treatment effect in opioid use disorder.
What this interaction means in plain words
Apalutamide and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated metabolism of buprenorphine increases its clearance.
What to do
Monitor for withdrawal, cravings and illicit opioid use, and consider supplemental dosing or an alternative to apalutamide. Reassess when apalutamide is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Apalutamide and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce buprenorphine concentrations from long-acting injection through enzyme induction. This could cause withdrawal symptoms or reduced treatment effect in opioid use disorder.
How serious is the interaction between Apalutamide and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal, cravings and illicit opioid use, and consider supplemental dosing or an alternative to apalutamide. Reassess when apalutamide is discontinued.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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