Drug interactions
Apalutamide + Buprenorphine transdermal
Severity: Moderate
Apalutamide and Buprenorphine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide strongly induces CYP3A4 and may reduce systemic buprenorphine exposure from the patch. Patients may experience inadequate analgesia or opioid withdrawal.
What this interaction means in plain words
Apalutamide and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated metabolism of buprenorphine increases its clearance.
What to do
Monitor pain control and withdrawal signs, and titrate the patch dose or add rescue analgesia as needed. Reassess the dose when apalutamide is stopped because exposure will rise as induction wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Buprenorphine transdermal?
MediHelp rates the interaction as moderate. Apalutamide and Buprenorphine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide strongly induces CYP3A4 and may reduce systemic buprenorphine exposure from the patch. Patients may experience inadequate analgesia or opioid withdrawal.
How serious is the interaction between Apalutamide and Buprenorphine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal signs, and titrate the patch dose or add rescue analgesia as needed. Reassess the dose when apalutamide is stopped because exposure will rise as induction wanes.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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