Drug interactions
Apalutamide + Carvedilol
Severity: Moderate
Apalutamide and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an enzyme inducer and may lower carvedilol exposure through increased metabolism. This could reduce blood pressure or heart failure control.
What this interaction means in plain words
Apalutamide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Carvedilol belongs to Cardiovascular.
Why it happens
Apalutamide induction of CYP2C9 and UGT enzymes increases carvedilol clearance.
What to do
Monitor blood pressure and heart rate and increase the carvedilol dose if effect is lost. Reassess after apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Carvedilol?
MediHelp rates the interaction as moderate. Apalutamide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is an enzyme inducer and may lower carvedilol exposure through increased metabolism. This could reduce blood pressure or heart failure control.
How serious is the interaction between Apalutamide and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and increase the carvedilol dose if effect is lost. Reassess after apalutamide is stopped.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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