Drug interactions
Apalutamide + Cenobamate
Severity: Moderate
Apalutamide and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may lower apalutamide exposure. Apalutamide may also reduce cenobamate levels, risking loss of seizure control.
What this interaction means in plain words
Apalutamide and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Cenobamate belongs to Central Nervous System.
Why it happens
Both drugs induce CYP3A4, and cenobamate increases metabolism of apalutamide.
What to do
Monitor seizure frequency and PSA or radiographic response. Adjust cenobamate dose as clinically needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Apalutamide with Cenobamate?
MediHelp rates the interaction as moderate. Apalutamide and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may lower apalutamide exposure. Apalutamide may also reduce cenobamate levels, risking loss of seizure control.
How serious is the interaction between Apalutamide and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and PSA or radiographic response. Adjust cenobamate dose as clinically needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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