Drug interactions
Apalutamide + Chlordiazepoxide
Severity: Moderate
Apalutamide and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide, a strong CYP3A4 inducer, may lower plasma levels of chlordiazepoxide and its active metabolites. This can reduce sedative, anxiolytic or alcohol-withdrawal efficacy.
What this interaction means in plain words
Apalutamide and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4, increasing the hepatic clearance of chlordiazepoxide.
What to do
Monitor clinical response and increase the chlordiazepoxide dose if needed. Consider lorazepam or oxazepam when reliable effect is required, for example in alcohol withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Apalutamide and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide, a strong CYP3A4 inducer, may lower plasma levels of chlordiazepoxide and its active metabolites. This can reduce sedative, anxiolytic or alcohol-withdrawal efficacy.
How serious is the interaction between Apalutamide and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the chlordiazepoxide dose if needed. Consider lorazepam or oxazepam when reliable effect is required, for example in alcohol withdrawal.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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